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The discovery of scientists can radically change the approach to the treatment of mental illness.
An international team of scientists has created detailed maps of the genetic, cellular, and structural composition of the human and primate brains. Funded by the National Institutes of Health's BRAIN Research Through Advancing Innovative Neurotechnologies initiative, this project provides a deeper understanding of the cellular basis of brain function and dysfunction, which can be the starting point for creating a new generation of targeted therapeutics for people with psychiatric and other brain disorders.
According to Joshua Gordon, director of the National Institute of Mental Health, new detailed maps of human and primate brain cells offer a framework for developing new treatments that target specific brain cells and circuits.
Key findings of the study:
The three papers present the first map of adult human brain cells, showing the transcriptional and epigenomic profile of the brain.
A study of the properties of cells in various brain regions in marmosets showed a link between the properties of cells in the adult brain and their properties at the developmental stage.
Analysis of the anatomy and physiology of neurons in the outer layer of the neocortex revealed differences between the human and mouse brains, which may indicate an evolutionary change associated with increased regulatory needs for more complex brain circuits in humans.
The central goal of the BICCN project, which aims to understand the cellular composition of the brain, is to develop a complete inventory of brain cells. These studies serve as a key milestone towards creating the brain therapies of the future and set the tone for the BRAIN Initiative's Network of Cell Atlases, an ambitious project aimed at changing the direction of neuroscience research by illuminating the basic principles governing behavior and shaping new approaches to treating brain diseases.
An international team of scientists has created detailed maps of the genetic, cellular, and structural composition of the human and primate brains. Funded by the National Institutes of Health's BRAIN Research Through Advancing Innovative Neurotechnologies initiative, this project provides a deeper understanding of the cellular basis of brain function and dysfunction, which can be the starting point for creating a new generation of targeted therapeutics for people with psychiatric and other brain disorders.
According to Joshua Gordon, director of the National Institute of Mental Health, new detailed maps of human and primate brain cells offer a framework for developing new treatments that target specific brain cells and circuits.
Key findings of the study:
The three papers present the first map of adult human brain cells, showing the transcriptional and epigenomic profile of the brain.
A study of the properties of cells in various brain regions in marmosets showed a link between the properties of cells in the adult brain and their properties at the developmental stage.
Analysis of the anatomy and physiology of neurons in the outer layer of the neocortex revealed differences between the human and mouse brains, which may indicate an evolutionary change associated with increased regulatory needs for more complex brain circuits in humans.
The central goal of the BICCN project, which aims to understand the cellular composition of the brain, is to develop a complete inventory of brain cells. These studies serve as a key milestone towards creating the brain therapies of the future and set the tone for the BRAIN Initiative's Network of Cell Atlases, an ambitious project aimed at changing the direction of neuroscience research by illuminating the basic principles governing behavior and shaping new approaches to treating brain diseases.
